Composition for antiseptic and other purposes.



H. S. BLAGKMORE. COMPOSITION FOR ANTISEPTIG AND OTHER PURPOSES.

APPLIOATION FILED AUG. 7, 1903.

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HENRY SPENCER BLAGKMORE, MOUNT VERNON, YORK.

COMPOSITION FOR ANTISEP'IIO AND OTHER PURPOSES.

Specification of Letters Patent.

ratenteama. 1 2, 003

Application filed August 7, 1908. Serial Ho. 168,678.

To all whom it may concern:

Be it known that I, HENRY Srnncnn Bmoxnoas a citizen of the United States, residing at lllount Vernon, in the county of Wcstchester and State of New York, have invented certain new and useful Im rovements in Compositions for Antiseptic and other Purposes; and I do hereby declare the following to be a full, clear, and exact description of the invention, such as will enable others skilled in the art to which it appertains to make and usethe same.

This invention relates to a new article of manufacture for disinfecting, germicide, antiseptic and medicinal purposes and process of making the same, and it consists of a mixture, compound, or solution of formic aldehyde or its polymerids in a fixed waterrepellent, such asfixed oils or fatty vehicles, which compounds or compositions may or may not be associated with other medicating agents, the object being to produce a fixed, fatty composition of water-repellent nature containing formic aldehyde which may be employed per 86 or as a vehicle for other medicating or medicinal agents As a specific illustration of my new composition and the manner in which the same is produced I will take, for example, the production of a solution of formic aldehyde 1n maize oil (corn oil) which oil consists largely of glycerol-oleic ester. he manner in which I prefer to produce this fixed water-repellent or oily formic aldehyde solution or compound is to place'the desired fixed oil, such as maize oil, in a proper container and expose it to the presence of for-- mic aldehyde under increased pressure at the same time agitating it, whereby the formic aldehyde becomes absorbed, occluded, or retained therein. When the fixed oil has become saturated with formic aldehyde it is removed, the formic aldehyde content ascertained by test, and the composition diluted with more oil to obtain the percentage content of formic aldehyde desired.

The polymerids of formic aldehyde, such as paraformaldehyde or trioxymethylene may be dissolved in the oil, preferably by the action of heat, producing compounds not departing from the spirit of my invention, as, upon heating in the formation of the composition, formic aldehyde is generated and the compositionis found to have a like disnal property, and to all lntents and pur poses may be considered, and is herein i11- cluded, as an equivalent composition in accordance with my invention.

The apparatus, in which the Solution of formic aldehyde in inert and fixed water repellent vehicles in accordance with my process is made, is illustrated in the accom' panying drawing, in which,

Figure l is a longitudinal vertical Section; 6h

Fig. 2 is a sectional view of an axial stuflingbox through which pass the inlet and outlet pipes for the purpose of heating the contents of the apparatus ,by means of steam;

Fig. 3 is a View of a perforated pipe through Whlcll the formic aldehyde is introduced into the apparatus.

In carrying out my invention for makin a solution of formic aldehyde in maize oif,

I introduce into the revoluble drum A,

maize or corn oil which consists largely of glycerol-oleic ester, through the opening B by removing the cover 6, sufiicient to-fill the drum about two-thirds full. if then place the cover I) over the opening B and malntain the same in a tight or closed position by means of the screw-clamp C. I then open the valves d in the pipes D and pass there- I through and through the coil 0 a current of steam, whereby the maize or corn oil in the drum A becomes heated. As soon as the oil has become heated to about 100 G, I introduce into the oil through the perforated I pipe X formic'aldehyde gas under a pressure of about 20 pounds by opening the valve 1. This formic aldehyde gas passes first through the check-valve H which provents the oil or other substances in the receptacle A from being forced back into the formic aldehyde reservoir or generating apparatus. Connected with the pipe F, through which the formic aldehyde gas under pressure passes to the coil X from which the formic aldehyde gas is discharged through the perforations :0, is a pressure 10o the drum A is revolved by means of the cogloo wheel M actuated by the movement of the revolving wheel N. In the axial ends of the drum A are the stuffing-boxes E and P, the v infectant, germicide, antiseptic, and m dici- 55 e pipes D passingthrough thefixed seccan be seen that tion a of the stuflingx E while the pipe F through which the formic aldehyde 1s intros duced into the a tus passes through the Xftlhe apparatus revolves,.

stufling-box P. the contents are siflilngltaifieplllisly heated by the steam assin' g e p1 the formic aldehyde is introduce through the pipe F, the premire bein maintained preferably at about 20 poun s. After. a suflicient amoimt of formic aldehyde has been introduced into the oil in the apparatus to produce the dedred percentage content, the'apparatus is maintained in a rotary con dition for abouttwo hours whereby the formic aldehyde becomes thoroughly dissolved in or assimilated with the oil by the agitative action of the revolving drum and the fixed steam-heating coil 0 and erforated coil 0: through which the formic-a dehyde is introduced; The revolution of the apparatus is then stop and the oil, charged with formic aldehy e, iswithdrawn through the pipeKb o provid atlts outer endwith aflangez or the purpose of coupling up or clamping to conuits le to aremrvoir for the fixed oil charged wit formic aldehyde. The whole apparatus is axially supported by the stands L through which the ends or hollow trunnions of the receptacle A are supported. It the and formlc aldehyde are thus thoro ymixed and assimilated by the action o heat and with the agitation caused y the revo ution of the drum, thus continually flowing the oil against the-fixed coils X and O.

I have found it of advanta to employ this anhydrous fixed water-repel containing formic aldehyde equivalent as a vehicle for a nts, such, for indzance, w 'ch case it'is found to tion as anantiseptic and application to or its described other medicinal as eucalyptol, in act with satisfachealin agept for suppura su aces r1n :35 about the d ctiol i dgd removal of t e ammatory or suppurating causes and at the'same time a parently acting as a local anesthetic and siereby relieving the pain with which such inflammations are usually accompanied. It is preferable that the formic vehicle, in cases of this kind, should not exceed' one tenth of one per cent., but it can be varied at the tion of the prescriber to meet the exigencies and idiosyncrasies of the case.

Insteadnof eucalyptol I can employ any other medicinal agent as desired, such as menthol, cocaine, morphine, etc., with the fixed oily formic aldehyde vehicle, or I can employ other fats, oils or ali hatic esters as the base for the formic aldehyde vehicle without departing from the spirit ofm invention, and I. intend to. inc ude the ense D and ,prevents the oily base from beco peningthevalvek. The pi e'Kis ressure to other ent composition repellent vehi e aldehyde content of the fixed oily fatty oils or fats, such as olein, or other aliphatic or 'oxy-acyd ester which may be of solid or semi-solid or fluid consistency at o I ressure and temperature, the

a ve Is for other medicating or m agents.

It is found that, aside from the advantages derived. from the employment of the fixed oily formic aldehyde compositions as a vehicle for other medicatinig or agents, that the formic al ehyde con tent oxidized or rancid and the compodtion is und complositions of which may be emplgyl to be of itself of great advantage as a hemostatic and when applied to cuts or wounds a rapid healing agent byreason of its antiseptic and coagulating action upon'the albummous content of theblood or exposed raw surfaces.

I am aware that formic aldehyde has been mixed in its aqueous solution emulsified with lard and with emulsions, such as milk, for the purpose of press the same, and I am also aware that formic aldehyde has been combined with hydrated collogen, such as is contained in gelatin, glues, slnns and hides, to renderthe said substances insoluble or transform them into leather, but it is seen hericr that in these cases the substances produced are not of water-re ent nature masmuch as water may be mixed with and absorbed by the said compositions with freedom, which is not the case with the fixed V oily or fatt formic aldehyde composition as produ b 'my procsm, which-waterdrous fixed aliphatic esters Mae-and not associated wit water in suspension in contradistinctjon from the aforesaid It may be noted that dry formic aldehyde, which is a unites or combines more readily with the fixed oils or ali hatic esters and becomes more with or re- .tained or occluded tl i nent manner and to a larger percen without danger of polymerization than is zfif case with aqueous solutions.

The term inert em loyed out this specification and claimshas reference to the character of the solvent for I the formic aldehyde and-its character in relation-to the formic aldehyde contmt; and the term .fixdeg oil to'the crude (ii-0:11- merci-al anh us, inert 1 water-1e lent, mineral; vegetable or animal fat or oil, as well as purified products or esters and s intended to include anhydrous, inert, fined water-re nature w 'ch might substances or artific1ally or prepared, it being understood.

fixed implies that thesubstance is of consists largely of anhy-' amorepermaent com tions of fined oily L syntheh y. thattbeterm non-volatile and permanent character under ordinary atmospheric pressure and temperature; and the term water-repellent designates a composition ordinarily insoluble in or incompatible with water.

Having now described by invention, what I claim as new and desire to secure by Letters Patent is 1. A new anhydrous composition of matter consisting of an inert, unctuous, fixed Fraser-repellent vehicle, and formic alde- 1y e.

2. A new anhydrous composition ofmatter consisting of an inert, unctuous, fixed water-repellent vehicle containing formic aldehyde.

3. A new anhydrous composition of matter composed of formic aldehyde and an inert fixed ester.

4. A new anhydrous com osition of matter composed of formic aldehyde and an inert fixed oxy-acid ester.

5. A new anhydrous composition of mat ter composed of formic aldehyde and an inert fixed aliphatic ester.

-6. A new anhydrous composition of matter substantially consisting of an inert fixed aliphatic ester and formic aldehyde.

7 A new anhydrous composition of matter com osed of an inert oleic ester and formic a dehyde.

8. A new composition of matter substantially composed of an inert fixed aliphatic ester, formic aldehyde and a medicating agent.

9. A new anhydrous composition of matter consistin of formic aldehyde and an inert fixed oil.

10. A new anhydrous composition of matter consisting of inert fixed oil and formic aldehyde.

11. As a vehicle for medicinal agents, an

'anhydrous composition com rising an inert fixed oily ester containing ormic aldehyde.

12. The rocess of making the new composition of matter herein set forth, which consists in mixing a fixed water-re llent ester with anhydrous formic aldehy e and exposing the same to intimate association until the formic aldehyde has become associated therewith or occluded therein.

13. The rocess of maln'ng the new composition of matter herein set forth which consists in mixing a fixed water-repellent ester with gaseous formic aldehyde and exposing the same to intimate association until the formic aldehyde has become associated therewith or occluded therein.

14. The rocess of making the new composition ofi matter herein set forth which consists in mixing a fixed water-repellent ester with formic aldehyde under superatmospheric pressure and exposing the same to intimate. association until the formic aldehyde has become associated therewith or 00- cluded therein.

In testimony whereof I afiix my signature, in presence of two witnesses.

V ---HENRY SPENCER BLACKMORE. Witnesses:

O. G. VICTOR, WALTER F. Nmzzmn 

